It can also be used in an enterprise environment as a productivity tool for conducting long distance group discussions. This would also help when using group collaboration programs that don't provide any kind of voice communication support.

A Ventrilo server could be setup in order to complement a web site that has voice interaction with its creators or for communicating with other people who share a common interest.

For those people that use Windows or Linux based firewall's to connect their internal home LAN's with the Internet can setup a server on the firewall computer so that friends and family can connect to your server and talk for free.

If voice communication isn't your cup of tea then you can always use Ventrilo as a more reliable form of IRC without the hassles or frustration of trying to teach someone how to setup a real IRC client.